Revisiting Organelle Behavior
With Dr. Sarah Cohen
Organelles and the secrets they tell.
From the lab of Dr. Sarah Cohen
Dr. Sarah Cohen, a biologist focused on neurodegenerative diseases, uses advanced microscopy for a deeper understanding of organelle behavior in living cells.
Observing subcellular interactions in live cells has unique challenges. Hundreds of organelles are in constant motion, making individual movements difficult to track. But Dr. Cohen uses fluorescent proteins to study their activity. The fluorescence lights up intracellular reactions as they take place, allowing her team to collect relevant data.
By focusing on organelle behaviors in neurodegenerative diseases, Dr. Cohen is identifying behavior patterns at a sub-cellular level which may lead to groundbreaking therapeutic options for diseases like Alzheimer’s and ALS.
Organelle dynamics
Under spectral imaging, 8 organelles labeled in different colors reveal morphology and dynamics.
Organelle morphology in 3D
Confocal microscopy enables optical sectioning, delivering a more precise 3D view of organelles within a live cell.
Organelle behavior
Labeled organelles in a colony of stem cells, shown in 3D at higher magnification to reveal more precise detail.
“It’s an amazing time to be a cell biologist. The recent explosion of microscopy techniques makes me feel like a kid in a candy store.”
Dr. Sarah Cohen uses multicolor and superresolution microscopy to study how cellular organelles reorganize in response to developmental and environmental cues, and how this goes awry in metabolic and neurodegenerative diseases.
Experience more breakthroughs and download Dr. Sarah Cohen’s full research report.
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